The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort
ARID1A mutation was associated with worse PFS for patients with NSMP. ARID1A protein expression was significantly associated with ARID1A mutation. ARID1A mutation, with ER/PR expression and PIK3CA mutation status, could serve as the potential biomarkers to subclassify NSMP subtype and provide more precise therapeutic target.
Authors
- Changmin YU
- Zhengyao Zhai
- Xiaoyan Zhou
- Yulan Ren
- Mengyuan Cai
- Xinhui Yuan
- Huaying Wang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1007/s00432-026-06440-w
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00