Role of Cytokines in Oligometastatic Non-Small-Cell Lung Cancer Treated with Stereotactic Radiation Therapy: An Observational Pilot Study
These findings suggest that SRT triggers measurable systemic immune activation in oligometastatic NSCLC, which is further shaped by tumor biology, disease burden, and concomitant systemic therapies. Although limited by the small sample size, this study supports the feasibility and potential utility of cytokine profiling to refine patient selection and guide biomarker-driven combinations of SRT with targeted and immune-based treatments, warranting validation in larger prospective cohorts.
Authors
- Francesca Di Pressa (ORCID: https://orcid.org/0000-0002-7191-3080)
- Lorenzo Granello (ORCID: https://orcid.org/0009-0006-7968-483X)
- Paolo Borghetti (ORCID: https://orcid.org/0000-0001-7275-7908)
- L. Triggiani
- Elisa D’Angelo (ORCID: https://orcid.org/0000-0002-5954-0939)
- Andrea Emanuele Guerini (ORCID: https://orcid.org/0000-0003-2094-1062)
- Giorgio Biasiotto (ORCID: https://orcid.org/0000-0001-7495-7807)
- Giorgio Facheris (ORCID: https://orcid.org/0000-0002-4555-1725)
- Stefania Bettelli (ORCID: https://orcid.org/0000-0002-3885-674X)
- Valerio Nardone (ORCID: https://orcid.org/0000-0002-7347-0965)
- Antonella Colosini
- A. Bruni
- M. Buglione Di Monale E Bastia
- Anna Gogna
- Roberto Bresciani
Institutions
- University of Modena and Reggio Emilia (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Alessandro Manzoni Hospital (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Ospedale Bellaria (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Biomolecules
- Published
- 2026-03-13
- DOI
- https://doi.org/10.3390/biom16030423
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Associazione Italiana per la Ricerca sul Cancro