Efficacy of finerenone in reducing proteinuria in diabetic kidney disease with maximum tolerable doses of dapagliflozin and telmisartan

Finerenone was associated with an overall reduction in albuminuria, with the magnitude of response varying according to baseline UACR. Greater proportional reductions were observed in patients with lower baseline albuminuria, while patients with moderate to severe albuminuria demonstrated a more heterogeneous response, including both responders and non-responders. Despite this variability, finerenone was generally safe and well tolerated. These findings support the use of finerenone as part of a multimodal strategy for proteinuria management in DKD, particularly as add-on therapy in patients receiving optimized RAAS blockade and SGLT2 inhibition, with the greatest benefit seen when introduced earlier in the course of albuminuric disease.

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Publication Details

Journal
World Journal of Nephrology
Published
2026-03-13
DOI
https://doi.org/10.5527/wjn.v15.i1.117173
Primary Topic
Hormonal Regulation and Hypertension
Type
article
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article

Efficacy of finerenone in reducing proteinuria in diabetic kidney disease with maximum tolerable doses of dapagliflozin and telmisartan

Mohit Kurundwadkar, Pranjal Kashiv, Vishal Ramteke, Manish Balwani et al.
World Journal of Nephrology
Hormonal Regulation and Hypertension
article

Efficacy of finerenone in reducing proteinuria in diabetic kidney disease with maximum tolerable doses of dapagliflozin and telmisartan

Mohit Kurundwadkar, Pranjal Kashiv, Vishal Ramteke, Manish Balwani, Shubham Dubey, Nishant Deshpande, A. Pasari, Vijay Jeyachandran, Kapil N Sejpal, Sunny Malde, Sushrut Gupta, Twinkle Pawar, Prasad Gurjar, Charulata Bawankule
article en

Abstract

Finerenone was associated with an overall reduction in albuminuria, with the magnitude of response varying according to baseline UACR. Greater proportional reductions were observed in patients with lower baseline albuminuria, while patients with moderate to severe albuminuria demonstrated a more heterogeneous response, including both responders and non-responders. Despite this variability, finerenone was generally safe and well tolerated. These findings support the use of finerenone as part of a multimodal strategy for proteinuria management in DKD, particularly as add-on therapy in patients receiving optimized RAAS blockade and SGLT2 inhibition, with the greatest benefit seen when introduced earlier in the course of albuminuric disease.

World Journal of NephrologyVol. 15(1)
Jawaharlal Nehru Medical College Hospital (IN), Government Medical College (IN), Nagpur Institute of Technology (IN), Max Super Speciality Hospital (IN), Jawaharlal Nehru Medical College (IN), Jawaharlal Nehru Medical College (IN), Saraswati Dental College and Hospital (IN), Central India Institute of Medical Sciences (IN), All India Institute of Medical Sciences, Nagpur (IN)
Good health and well-being
Openalex Percentile: Top 24%
Hormonal Regulation and Hypertension
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