Emergence of Carbapenem-Resistant <i>Escherichia coli</i> Coharboring <i>bla</i> CTX-M-199 and Penicillin-Binding Protein 3 Insertion Conferring Increased Aztreonam/Avibactam Resistance in South China
These findings suggest that blaCTX-M-199 contributes to reduced ATM/AVI susceptibility and, in synergy with YRIK/YRIN insertions, likely confers significant ATM/AVI resistance. Notably, CREC strains coharboring blaCTX-M-199 and YRIK/YRIN insertions are emerging within international high-risk clones ST410 and ST167. Therefore, our study highlights the importance of monitoring the prevalence of blaCTX-M-199-harboring CREC and implementing its detection in clinical practice.
Authors
- Qinhong Xie
- Likang Yao (ORCID: https://orcid.org/0009-0009-5915-8754)
- Qiuxue Deng
- Yong Qing Jiang (ORCID: https://orcid.org/0000-0002-0490-3405)
- Yingyi Guo (ORCID: https://orcid.org/0000-0001-9112-687X)
- Jianjun Wang (ORCID: https://orcid.org/0000-0001-7039-7136)
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Xun Zhang (ORCID: https://orcid.org/0000-0003-3586-9921)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
- Jiayi Xu (ORCID: https://orcid.org/0000-0003-3465-7927)
- Shunian Xiao
- Yexin Lin
- Suran Xu
- Jiahui Li
- Hualiang Chen
- Chao Zhuo
Institutions
- Kunming University of Science and Technology (CN)
- Sun Yat-sen University (CN)
- Sir Run Run Shaw Hospital (CN)
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Huizhou Central People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
- Guangzhou Medical University (CN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/infdis/jiag025
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 21.79