Infection of ratites with clade 2.3.4.4b HPAIV H5N1: Potential implications for zoonotic risk
We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (<i>Rhea americana</i>). Viral genetic analysis revealed the mammalian associated PB2-E627 K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.
Authors
- Natalie McGinn
- Richard Hepple
- Jayne Cooper
- James Seekings (ORCID: https://orcid.org/0000-0002-4519-262X)
- Holly A. Coombes (ORCID: https://orcid.org/0000-0002-4941-6328)
- Jacob Terrey
- Audra-Lynne Schlachter
- Barry Clifton
- Phoebe McCarter
- Isabella Regina
- Ashley C. Banyard
- Joe James
- Alejandro Nunez
- Benjamin C. Mollett
- Marco Falchieri
- Scott M. Reid
Institutions
- Animal and Plant Health Agency (GB)
- African Field Epidemiology Network (UG)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1080/22221751.2026.2645853
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.00