A stereotactic injection method to establish a clinically relevant germinal matrix hemorrhage murine model
Our group developed a GMH/posthemorrhagic hydrocephalus (PHH) mouse model with reproducible stereotactic injection coordinates. This model provides a foundation for future studies using genetically modified mouse strains aimed to advance understanding of the inflammation-related molecular mechanisms underlying acquired hydrocephalus and to support the preclinical evaluation of potential therapeutic interventions.
Authors
- Michael G. Muhonen
- Brian W. Hanak (ORCID: https://orcid.org/0000-0002-3155-7413)
- Gio Jison (ORCID: https://orcid.org/0009-0009-4677-411X)
- Amirhossein Shahriari
- Sydney Milo
- Sora Sato
- Celine Thao-Quyen Tran
- Noah Ramos (ORCID: https://orcid.org/0009-0001-9086-4587)
- Spencer Sabahat
- Michael Le
- Leandro Castañeyra-Ruiz
- Alejandra Padilla
- Alexandra Latini
- Seunghyun Lee
- Evelyn Torres
Institutions
- Children's Hospital of Orange County (US)
- Universidade Federal de Santa Catarina (BR)
Publication Details
- Journal
- Journal of Neuroscience Methods
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1016/j.jneumeth.2026.110741
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00