Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma
TFF3 is a hypoxia-inducible factor that enhances HB cell proliferation, survival and chemoresistance. Its tumour-promoting activity through C-MYC and mTOR pathways identifies TFF3 as a potential therapeutic target and circulating biomarker in hepatoblastoma.
Authors
- Melva Gutiérrez‐Angulo (ORCID: https://orcid.org/0000-0003-3848-8892)
- Rebeca Bataller
- Pau Sancho‐Bru (ORCID: https://orcid.org/0000-0001-5569-9259)
- Luz Andrea Martínez‐Pérez (ORCID: https://orcid.org/0000-0002-9215-4458)
- Pavel Strnad (ORCID: https://orcid.org/0000-0003-3164-9614)
- Maurizio Parola (ORCID: https://orcid.org/0000-0001-7720-5141)
- Carmen Berasain (ORCID: https://orcid.org/0000-0001-7075-2476)
- Beatrice Foglia (ORCID: https://orcid.org/0000-0001-7973-9681)
- M. Ávila
- Ondřej Fabián (ORCID: https://orcid.org/0000-0002-0393-2415)
- Eva Sticová (ORCID: https://orcid.org/0000-0003-2486-6266)
- Josepmaria Argemí (ORCID: https://orcid.org/0000-0003-1696-7753)
- Maite G. Fernández‐Barrena (ORCID: https://orcid.org/0000-0003-0375-6236)
- María Arechederra (ORCID: https://orcid.org/0000-0002-4830-1924)
- C Armengol
- Bruno Sangro (ORCID: https://orcid.org/0000-0002-4177-6417)
- Jasmin Elurbide
- Jessica Marin
- Stefano Cairo
- Iker Uriarte
- M. Ujue Latasa
- Sona Frankova
- Maria L. Martinez‐Chantar
- Amaya López‐Pascual
- Eva Santamaria
- Andrea Castaneda
Institutions
- Universidad de Salamanca (ES)
- Universidad de Guadalajara (MX)
- Charles University (CZ)
- Navarre Institute of Health Research (ES)
- CIC bioGUNE (ES)
- Universitätsklinikum Aachen (DE)
- Institute of Clinical and Experimental Medicine (CZ)
- Torino e-district (IT)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Clinica Universidad de Navarra (ES)
- Champions Oncology (United States) (US)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Thomayer University Hospital (CZ)
- University Hospital Kralovske Vinohrady (CZ)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University of Turin (IT)
- Universidad de Navarra (ES)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Liver International
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1111/liv.70592
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00