Cerebral Autoregulation, Mannitol Response, and Outcomes in Traumatic Brain Injury: A Structural Causal Model Approach
PRx before mannitol and RMannitol causality suggests that compensatory cerebral vasoconstriction drives mannitol response. RMannitol and GOSE inverse relationship underscores the importance of ICP monitoring and timely treatment escalation. The PRx before mannitol, RMannitol, and GOSE causal relationship suggests that considering both RMannitol and PRx may improve patient outcomes. SCMMannitol may estimate heterogeneous treatment effects, advancing precision medicine for patients with traumatic brain injury.
Authors
- Se-Hyuk Kim (ORCID: https://orcid.org/0000-0002-7528-4007)
- Jae-Wook Heo
- Tae Hoon Roh (ORCID: https://orcid.org/0000-0002-1004-9364)
- Dong‐Joo Kim (ORCID: https://orcid.org/0000-0002-0988-2236)
- Min-Kyung Jung (ORCID: https://orcid.org/0000-0001-7580-0297)
- Eun Jin Ha
- Namkyu You
- Hakseung Kim
- Hyub Huh
Institutions
- Yonsei University (KR)
- Korea University (KR)
- Seoul National University Hospital (KR)
- Kyung Hee University (KR)
- International Neuromodulation Society (US)
- Ajou University (KR)
Publication Details
- Journal
- Neurosurgery
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1227/neu.0000000000003984
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00