Complete locoregional response to radiotherapy and pembrolizumab in an elderly and frail patient with oropharyngeal squamous cell carcinoma: A case report
This case supports the hypothesis of synergism between RT and immunotherapy in an elderly and frail patient with advanced head and neck squamous cell carcinoma. Hypofractionated RT on the primary tumor alone, combined with ICIs, may lead to sustained locoregional control. Immune-related hepatic toxicity, while clinically significant, did not preclude stable disease.
Authors
- Viola Laghi
- Karim Rihawi (ORCID: https://orcid.org/0000-0002-3915-466X)
- Mirta Mosca
- Ambrogio Gagliano
- Daria Maria Filippini (ORCID: https://orcid.org/0000-0003-3328-7282)
- Elisabetta Nobili
- G. Siepe (ORCID: https://orcid.org/0000-0001-6308-1694)
- Flaminia Benedetta Zoboli
Institutions
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Medicine
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1097/md.0000000000047050
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00