Deficiency of the Mycobacterial Lipoarabinomannan Biosynthesis Glycosyltransferase MptC Enhances Antibacterial Immune Response and Rifapicin Antibiotic Susceptibility
Mannosyltransferase MptC plays an important role in maintaining cell wall integrity (via LM/LAM synthesis), regulating T cell responses, and influencing antibiotic susceptibility in mycobacteria.
Authors
- Yi-Cheng Sun
- Z. T. Sun (ORCID: https://orcid.org/0009-0005-5843-499X)
- Jiaxin Hu
- Zhongkun Li
- Xiao-Lian Zhang
- Hongliang Chen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Antibiotics
- Published
- 2026-03-13
- DOI
- https://doi.org/10.3390/antibiotics15030291
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuhan University
- National Science and Technology Major Project