Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty

In older adults with heart failure, approximately one-third discontinued GDMT within 12 months, and discontinuation appeared disproportionately common among those with frailty.

Authors

Ryo Nakamaru (ORCID: https://orcid.org/0000-0002-0129-7219)
Shiori Nishimura (ORCID: https://orcid.org/0000-0003-1319-3158)
Shun Kohsaka (ORCID: https://orcid.org/0000-0003-3779-2972)
Kyohei Daigo (ORCID: https://orcid.org/0000-0003-2590-8966)
Kayo Walsh
Hiraku Kumamaru

Institutions

Kyorin University (JP)
Keio University (JP)
The University of Tokyo (JP)
Yokohama City University (JP)

Publication Details

Journal: Journal of the American Heart Association
Published: 2026-03-13
DOI: https://doi.org/10.1161/jaha.125.047638
Primary Topic: Heart Failure Treatment and Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty

Ryo Nakamaru, Shiori Nishimura, Shun Kohsaka, Kyohei Daigo et al.

Mar 13, 2026

Journal of the American Heart Association

Heart Failure Treatment and Management

article

Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty

Ryo Nakamaru, Shiori Nishimura, Shun Kohsaka, Kyohei Daigo, Kayo Walsh, Hiraku Kumamaru

March 13, 2026article en

Abstract

In older adults with heart failure, approximately one-third discontinued GDMT within 12 months, and discontinuation appeared disproportionately common among those with frailty.

Journal of the American Heart AssociationVol. 15(6)

Kyorin University (JP), Keio University (JP), The University of Tokyo (JP), Yokohama City University (JP)

Good health and well-being

Openalex Percentile: Top 31%

Heart Failure Treatment and Management

DOI Open Access PDF OpenAlex

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Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty — Ryo Nakamaru, Shiori Nishimura, et al. · Journal of the American Heart Association (2026) | TGRS Research Map | TGRS