Functional and effective connectivity disruptions of the dopaminergic reward circuit in multiple sclerosis patients with depression
The present connectivity study revealed promising results for understanding the pathophysiology of depression in MS. A combined FC-EC investigation of the reward circuit may represent a potential non-invasive in vivo MRI biomarker for understanding the onset of core depressive symptoms, supporting the development of effective and personalised therapies.
Authors
- Giada Lombardi (ORCID: https://orcid.org/0009-0002-7749-307X)
- Emilio Cipriano (ORCID: https://orcid.org/0000-0003-0304-0529)
- Lucio Ghio
- Tommaso Sirito (ORCID: https://orcid.org/0000-0002-9016-8709)
- Elisa Leveraro (ORCID: https://orcid.org/0009-0005-0018-4449)
- Lorenza Nasone
- A. Escelsior
- M. Inglese
- Gianluca Serafini
- Maria Cellerino
Institutions
- Terminal San Giorgio (Italy) (IT)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1136/jnnp-2025-336798
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00