Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma
These data map the microenvironmental and transcriptional changes associated with rapid CAR-T cell dysfunction in GB and identify candidate pathways and regulators that may be leveraged to engineer more durable cellular therapies.
Authors
- Jan Kueckelhaus
- Nicolas Neidert (ORCID: https://orcid.org/0000-0003-0299-1138)
- Jasmin von Ehr
- Yahaya A Yabo (ORCID: https://orcid.org/0000-0002-1128-6038)
- Thomas Look (ORCID: https://orcid.org/0000-0001-5410-6220)
- Junyi Zhang (ORCID: https://orcid.org/0000-0002-0001-2971)
- Jasim Kada Benotmane
- Dieter Henrik Heiland
- Tobias Weiss
Institutions
- Northwestern University (US)
- University of Freiburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Zurich (CH)
- University Medical Center Freiburg (DE)
- Hochschule für Musik Freiburg (DE)
- Universitätsklinikum Erlangen (DE)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1186/s12916-026-04783-2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00