CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

Our study identified a METTL3/IGF2BP1-CKS2 axis that promotes OS progression <i>via</i> m<sup>6</sup>A-dependent mRNA stabilization, highlighting CKS2 as a potential therapeutic target.

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Publication Details

Journal
International Reviews of Immunology
Published
2026-03-13
DOI
https://doi.org/10.1080/08830185.2026.2641449
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

Li Zhang, Zhiyong Feng
International Reviews of Immunology
RNA modifications and cancer
article

CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

Li Zhang, Zhiyong Feng
article en

Abstract

Our study identified a METTL3/IGF2BP1-CKS2 axis that promotes OS progression <i>via</i> m<sup>6</sup>A-dependent mRNA stabilization, highlighting CKS2 as a potential therapeutic target.

International Reviews of Immunology
Wuhan Puai Hospital (CN)
Openalex Percentile: Top 23%
RNA modifications and cancer
DOISourceOpenAlex
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