The impact of slope-adjusted visit-to-visit body mass index variability on early dementia risk prediction
Slope-adjusted visit-to-visit BMI variability is independently associated with dementia risk, particularly among females, while BMI decline patterns are strong risk factors of dementia. Incorporating longitudinal monitoring of visit-to-visit BMI variability into routine dementia screening may be beneficial.
Authors
- Takahisa Murakami (ORCID: https://orcid.org/0000-0002-1405-8532)
- Seiya Izumi (ORCID: https://orcid.org/0009-0000-7683-0877)
- Maya Toyama
- Yutaro Iwabe (ORCID: https://orcid.org/0009-0008-1494-5319)
- Hiroki Nobayashi (ORCID: https://orcid.org/0000-0002-1783-8024)
- Michihiro Satoh (ORCID: https://orcid.org/0000-0003-1688-1239)
- Takahito Yagihashi
- Yuya Suzuki (ORCID: https://orcid.org/0000-0002-6790-0914)
- Hirohito Metoki (ORCID: https://orcid.org/0000-0002-1894-3328)
- Juichi Fujimori (ORCID: https://orcid.org/0000-0001-7170-7853)
- Tomoko Muroya
- Shingo Nakayama
Institutions
- Jikei University School of Medicine (JP)
- Cedars-Sinai Medical Center (US)
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Miyagi Prefectural Hospital Organization (JP)
- Izumi City General Hospital (JP)
- Tohoku Medical Megabank Organization (JP)
- Tohoku Medical and Pharmaceutical University Hospital (JP)
- Sendai City Hospital (JP)
- Self-Defense Forces Central Hospital (JP)
- Sendai Shakai Hoken Hospital (JP)
- Southern Tohoku General Hospital (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1038/s41366-026-02052-z
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bayer Yakuhin
- Japan Society for the Promotion of Science