Front Cover: pH‐Responsive Isoprenoid‐Antitumoral Polymer Conjugates for Superior Drug Loading via Self‐Assembly and Endosomal‐Targeted Anticancer Activity (ChemMedChem 5/2026)

The image illustrates the pH-responsive Farnesal-Poly-Lysine conjugates that self-assemble into nanoparticles for better cellular delivery. The nanoparticles can enter cancer cells by endocytosis and release their active components (Farnesal and ε-Poly-Lysine) under acidic endosomal conditions. The artwork highlights self-assembled nanoparticle formation, cellular uptake, and selective intracellular drug liberation, visualizing the targeted delivery concept explored in the article. More details can be found in the Research Article by Marc Schneider, Sangeun Lee, and co-workers (DOI: 10.1002/cmdc.202500810). Figure created in BioRender.