Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury
This study demonstrates an unexpected protective role for VEGF-D in promoting lung endothelial barrier integrity and suggests that paracrine signaling from the alveolar fibroblast niche contributes critically to lung capillary homeostasis.
Authors
- Johad Khoury (ORCID: https://orcid.org/0000-0001-8048-1542)
- Wenwen Tang (ORCID: https://orcid.org/0000-0001-9234-4385)
- Yongdae Yoon (ORCID: https://orcid.org/0000-0002-9229-9331)
- Qianying Yuan (ORCID: https://orcid.org/0000-0002-4972-3264)
- Shannon Kirk
- Konstantin G. Birukov (ORCID: https://orcid.org/0000-0002-0303-5394)
- Lokesh Sharma (ORCID: https://orcid.org/0000-0002-9979-1900)
- Hong Qian (ORCID: https://orcid.org/0000-0003-0364-6301)
- Lujia Chen (ORCID: https://orcid.org/0000-0002-9853-2413)
- Dianqing Wu
- Mohan E. Tulapurkar (ORCID: https://orcid.org/0009-0006-1677-9129)
- Ruya Liu
- Yifan Yuan
- M. Sam Brickman Raredon
- Farida Ahangari
- Yi Luan
- Laura E. Niklason
- Naftali Kaminski
- Michael Simons
- Yunbo Ke
Institutions
- University of Maryland, Baltimore (US)
- University of Pittsburgh (US)
- Yahoo (Spain) (ES)
- Yale University (US)
- Humacyte (United States) (US)
- Pulmonary and Allergy Associates (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1161/circresaha.124.326094
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00