Development and Evaluation of Compact Semi-Synthetic Promoters for Enhanced Antigen Expression in Adenoviral-Vectored Vaccines
We have successfully developed semi-synthetic promoters that match the potency of the much larger, frequently used CMV promoters whilst simultaneously reducing genomic footprint. These novel regulatory elements will facilitate the design of next-generation vaccines, particularly those requiring large antigens or multi-antigen cassettes.
Authors
- Marta Ulaszewska (ORCID: https://orcid.org/0000-0003-4288-2892)
- Bruno Douradinha (ORCID: https://orcid.org/0000-0002-9980-4505)
- Sarah C. Gilbert (ORCID: https://orcid.org/0000-0002-6823-9750)
- Zakia Al-Hareth (ORCID: https://orcid.org/0000-0003-3909-0528)
- Bárbara Dema (ORCID: https://orcid.org/0000-0002-1692-9987)
- Susan Morris (ORCID: https://orcid.org/0009-0000-1813-0557)
- Matěj Hlaváč
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University of Oxford (GB)
Publication Details
- Journal
- Vaccines
- Published
- 2026-03-13
- DOI
- https://doi.org/10.3390/vaccines14030260
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Oxford