A phase 1 study of berzosertib (M6620, VX‐970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)
Berzosertib (200 mg/m<sup>2</sup> iv weekly) was safe when combined with chemoradiation but did not improve complete response rate in LA-HNSCC.
Authors
- Michael A. Carducci (ORCID: https://orcid.org/0000-0002-7908-1215)
- John C. Schmitz (ORCID: https://orcid.org/0000-0001-6321-9606)
- Darrion Mitchell (ORCID: https://orcid.org/0000-0003-1733-9644)
- V.M. Diavolitsis
- Brian F. Kiesel (ORCID: https://orcid.org/0000-0002-4214-7524)
- Taofeek K. Owonikoko (ORCID: https://orcid.org/0000-0002-7724-7728)
- Moon J. Fenton (ORCID: https://orcid.org/0000-0002-6483-0009)
- Barbara Ann Burtness (ORCID: https://orcid.org/0000-0003-4660-1859)
- Susanne M. Arnold (ORCID: https://orcid.org/0000-0001-6542-9551)
- Dan Paul Zandberg (ORCID: https://orcid.org/0000-0002-1002-8301)
- Zhengjia Chen (ORCID: https://orcid.org/0000-0002-6301-4931)
- Charles A. Kunos
- Garrett T. Wasp (ORCID: https://orcid.org/0000-0002-1224-717X)
- J. J. Beumer
- Aarti Bhatia (ORCID: https://orcid.org/0000-0002-0491-4454)
- Harold H. Tara
- Jonathan Wesley Riess (ORCID: https://orcid.org/0000-0001-7370-7304)
- Varinder Kaur (ORCID: https://orcid.org/0000-0002-6480-7204)
- Priyanka Bhateja (ORCID: https://orcid.org/0000-0001-9515-0498)
- D. M. Shin
- Yuji Zhang
- Malini Patel
- Conor E. Steuer
- Steven D. Gore
- Justine Yang Bruce
- Nabil F. Saba
- Thomas H. Davis
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Maryland, Baltimore (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- University of Pittsburgh (US)
- Markey Cancer Center (US)
- Yale Cancer Center (US)
- University of Illinois Chicago (US)
- Dartmouth Psychiatric Research Center (US)
- UPMC Hillman Cancer Center (US)
- National Cancer Institute (US)
- Sylvester Comprehensive Cancer Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Rutgers Cancer Institute (US)
- Dartmouth Cancer Center
- University of Virginia (US)
- The Ohio State University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Cancer
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1002/cncr.70346
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00