Acod1/itaconate axis controls anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice
Our findings demonstrate that the Acod1/itaconate axis plays an important role in regulating anxiety-like behavior by modulating neuroinflammation during chronic T. gondii infection. These results reveal a promising immune-metabolic drug target for treating T. gondii-associated neuropsychiatric conditions.
Authors
- Yujuan Shen
- Ziyi Yan
- Yingting Huang
- Fenfen Sun
- Huiling Lv
- Heng Deng
- Xinde Jiang
- Wei Pan
- Yumeng Zhou
- Siyu Li
- Yan He
- Yifan Zhang
- Yumei Zhang
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- National Institute for Parasitic Diseases (CN)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1371/journal.pntd.0014077
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00