Effects of different preoxygenation strategies on dynamic thiol-disulfide homeostasis and blood gas parameters in patients undergoing laparoscopic cholecystectomy

Standard preoxygenation was found to induce greater oxidative stress and metabolic disturbances compared to rapid preoxygenation. Incorporating rapid preoxygenation into anesthesia induction protocols may enhance perioperative safety by preserving redox balance and reducing metabolic derangements. These results underscore the need to reevaluate current preoxygenation practices, particularly in metabolically vulnerable patients. Further studies should assess long-term outcomes and applicability in high-risk populations.