Patterns of motor nerve demyelination and their prognostic significance in multifocal motor neuropathy

A pattern of early nerve involvement with prominent TD appears to be associated with a more aggressive disease course and poorer IVIg response. Diagnostic evaluation in MMN should not focus solely on focal CB but also systematically assess the number of nerves with TD. Prospective studies with standardized protocols are needed to validate these findings.

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Publication Details

Journal
IBRO Neuroscience Reports
Published
2026-03-13
DOI
https://doi.org/10.1016/j.ibneur.2026.03.005
Primary Topic
Peripheral Neuropathies and Disorders
Type
article
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article

Patterns of motor nerve demyelination and their prognostic significance in multifocal motor neuropathy

Andreas Posa, Malte Erich Kornhuber, Alexander Emmer, Tobias Biefel
IBRO Neuroscience Reports
Peripheral Neuropathies and Disorders
article

Patterns of motor nerve demyelination and their prognostic significance in multifocal motor neuropathy

Andreas Posa, Malte Erich Kornhuber, Alexander Emmer, Tobias Biefel
article en

Abstract

A pattern of early nerve involvement with prominent TD appears to be associated with a more aggressive disease course and poorer IVIg response. Diagnostic evaluation in MMN should not focus solely on focal CB but also systematically assess the number of nerves with TD. Prospective studies with standardized protocols are needed to validate these findings.

IBRO Neuroscience ReportsVol. 20
Luther University (KR), Institute of Pathology Celle (DE), Allgemeines Krankenhaus Celle (DE), Helios Kliniken (DE), Martin Luther University Halle-Wittenberg (DE)
Good health and well-being
Openalex Percentile: Top 31%
Peripheral Neuropathies and Disorders
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