Evaluation of sNfL as a Biomarker for Paclitaxel-Induced Peripheral Neurotoxicity Through an Integrated PKPD Model
Overall, the model successfully described the relationship between paclitaxel exposure and sNfL kinetics, offering a model-based framework for translational studies.
Authors
- Irena Loryan (ORCID: https://orcid.org/0000-0002-1557-4416)
- Mohamed Slaoui
- Jérôme Busserolles (ORCID: https://orcid.org/0000-0001-7542-9520)
- Franck Chanut (ORCID: https://orcid.org/0000-0001-8189-7400)
- David Balayssac (ORCID: https://orcid.org/0000-0002-6126-6588)
- Gautier Roussignol
- Lorenzo Di Cesare Mannelli (ORCID: https://orcid.org/0000-0001-8374-4432)
- Lena E. Friberg (ORCID: https://orcid.org/0000-0002-2979-679X)
- Olivier Perrault
- Milda Girdenyté (ORCID: https://orcid.org/0000-0002-3701-3847)
- Nathalie Le Berre
- Yang Hu
- Diethilde Theil
- Eman I. K. Ibrahim
Institutions
- Roche (Switzerland) (CH)
- Uppsala University (SE)
- Inserm (FR)
- Vilnius University (LT)
- Sanofi (France) (FR)
- University of Clermont Auvergne (FR)
- Novartis (United States) (US)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- BioNTech (Germany) (DE)
- Clermont Université (FR)
- University of Florence (IT)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1007/s11095-026-04053-z
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet
- Uppsala Universitet
- Science for Life Laboratory