Total flavonoids of Rhizoma drynariae targets NRF2-mediated anti-ferroptosis in osteoblasts to promote induced membrane osteogenesis
The NRF2-mediated anti-ferroptosis effect in osteoblasts positively regulated the mineralization of osteoblasts. The main components of TFRD targeted NRF2 in osteoblasts within the IMT bone grafting area, maintained its stability, promoted the expression of downstream antioxidant response elements (ARE), enhanced the anti-ferroptosis role of osteoblasts, thereby accelerating the repair of bone defects.
Authors
- S Li
- Qishi Zhou
- Qunbin Cai
- Dawen Yang
- Zhanpeng Zeng
Institutions
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1186/s13020-026-01347-7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00