Neutrophil membrane-coated and MMP2-responsive nanoparticles deliver PIM1 inhibitor to alleviate inflammatory arthritis through inhibiting Th17 cell differentiation
These results suggested that NM@MRP-NP was a structurally defined, biologically stable, inflammatory-targeted and conditionally releasing nanotherapeutic system with efficient drug delivery, which could provide new insight into the targeted interventions for IA.
Authors
- Ziqian Liu (ORCID: https://orcid.org/0000-0003-4289-5802)
- Zepeng Su (ORCID: https://orcid.org/0000-0001-7691-7075)
- Weihao Zhang (ORCID: https://orcid.org/0000-0002-9301-8538)
- Yipeng Zeng
- Yangfeng Lin
- Zibin Chen
- Qibo Li
- Guan Zheng (ORCID: https://orcid.org/0000-0001-8634-1030)
- Jiajie Lin
- Wenhui Yu
- Lihua Li
- Zhongyu Xie
Institutions
- Sun Yat-sen University (CN)
- South China Normal University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1186/s12951-026-04280-x
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00