Obesity, low-grade inflammation, and inflammatory response to immune challenge modulate willingness to expend effort for reward
Lipopolysaccharide-induced and low-grade inflammation may alter how effort is allocated towards reward: low-grade inflammation reduced the willingness to expend effort, while acute inflammation dampened reward sensitivity. This study offers a nuanced understanding of inflammatory processes underlying alterations in reward motivation.
Authors
- Michael T. Treadway (ORCID: https://orcid.org/0000-0002-5913-114X)
- Iris Ka-Yi Chat (ORCID: https://orcid.org/0000-0003-2448-5877)
- Johannes Hebebrand (ORCID: https://orcid.org/0000-0001-5364-6073)
- Till Hasenberg (ORCID: https://orcid.org/0000-0003-2681-8006)
- Lina S. Hansson (ORCID: https://orcid.org/0000-0002-3561-8092)
- Julie Lasselin (ORCID: https://orcid.org/0000-0001-8323-0714)
- Analena Handke (ORCID: https://orcid.org/0009-0000-9472-8956)
- Charlotta Jacobsen (ORCID: https://orcid.org/0000-0001-7991-8751)
- Vera Bender
- Manfred Schedlowski
- Harald Engler
- Sven Benson
- Robert Dantzer
- Mats Lekander
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Sana Kliniken AG (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1016/j.bbi.2026.106548
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00