Genetic Regulation of Wnt/PCP Components Through Fgf10/Fgfr2/Sox9 Module in Tear Duct Development
This study uncovers a previously unrecognized direct genetic link between Fgf signaling and Wnt/PCP pathway in tear duct formation, suggesting that Wnt/PCP components may represent potential risk factors for congenital nasolacrimal duct obstruction (CNLDO), warranting further investigation.
Authors
- Yingchun Su (ORCID: https://orcid.org/0000-0003-1307-2153)
- Shujuan Xu (ORCID: https://orcid.org/0000-0003-1802-7917)
- Shanzhen Peng
- Lijing Xie
- Jiali Ru
- Rong Ju
- Xuri Li (ORCID: https://orcid.org/0000-0002-8277-0767)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Lei Shi (ORCID: https://orcid.org/0000-0002-6043-8819)
- Rongxin Chen (ORCID: https://orcid.org/0000-0003-4867-8331)
- Mingjuan Wu (ORCID: https://orcid.org/0000-0002-3272-5407)
- Chunqiao Liu (ORCID: https://orcid.org/0000-0002-1513-0073)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0002-1752-5482)
- Dianlei Guo
- Mingzhu Guo
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1167/iovs.67.3.30
- Primary Topic
- Nasolacrimal Duct Obstruction Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00