Metal Free and Chemoselective Alkylation of Thiols with Thianthrenium Salts in Water
The metal-free method for the chemoselective S- and O-alkylation of thiols, and carboxylic acids using alkylthianthrenium salts was disclosed. This simple, sustainable protocol operates in water under ambient conditions, exhibits excellent chemoselectivity and broad scope. Its utility is demonstrated by one-pot reactions and isotopic labeling, offering a valuable platform for forming C-S and C-O bonds.
Authors
- Mengjuan Yu
- Zunan Gu
- W. X. Zhang
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Jing Yan (ORCID: https://orcid.org/0000-0002-7436-2907)
- Chi Yang (ORCID: https://orcid.org/0000-0002-3436-8554)
- Jianxing Liu (ORCID: https://orcid.org/0000-0002-2201-3887)
- Xi-Sheng Wang
- Biao Wei
Institutions
- University of Science and Technology of China (CN)
- Fuyang Normal University (CN)
- Guizhou University (CN)
- Hefei National Center for Physical Sciences at Nanoscale (CN)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1021/acs.joc.5c03156
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00