The dolutegravir failure cohort: A multi-country longitudinal cohort with a randomised clinical trial of continued dolutegravir versus switch to darunavir in people with viraemia while on dolutegravir in Sub-Saharan Africa (The Ndovu Study) protocol
The Ndovu study will address critical gaps in the management of DTG failure including the emergence, determinants and implications of DTG resistance. Further, it will evaluate the optimal ART regimens to use in the setting of DTG resistance in adults and children.
Authors
- Daniel J. Grint (ORCID: https://orcid.org/0000-0001-8001-6544)
- Charles Opondo (ORCID: https://orcid.org/0000-0001-8155-4117)
- Dalton C. Wamalwa (ORCID: https://orcid.org/0000-0002-5510-462X)
- Victor Omodi
- Irene Ayakaka (ORCID: https://orcid.org/0000-0003-1051-5684)
- Patricia Munseri (ORCID: https://orcid.org/0000-0002-8754-2755)
- Lisa Abuogi (ORCID: https://orcid.org/0000-0003-1492-5090)
- James Wagude (ORCID: https://orcid.org/0000-0003-4793-9296)
- Patrick Amoth (ORCID: https://orcid.org/0000-0001-8049-0879)
- Edwin T. Kamau (ORCID: https://orcid.org/0000-0002-5761-7883)
- Loice Achieng Ombajo (ORCID: https://orcid.org/0000-0003-4632-8792)
- Jeremy Penner (ORCID: https://orcid.org/0000-0001-6443-1748)
- Joseph Nkuranga (ORCID: https://orcid.org/0000-0002-9868-2948)
- Edwin Otieno
- Andrew Mulwa
- AnneMarie Macharia
- Leonard King’wara
- on behalf of the ESUR Prostate MRI Working Group
- Patricia Ramgi
- Raquel Matavele Chissumba
- Niklaus Labhardt
- Rena Patel
- Nalia Ismael
- Muhammad Bakari
Institutions
- University of Nairobi (KE)
- University of British Columbia (CA)
- Muhimbili University of Health and Allied Sciences (TZ)
- University Hospital of Basel (CH)
- Kenyatta National Hospital (KE)
- University of Alabama at Birmingham (US)
- London School of Hygiene & Tropical Medicine (GB)
- National Aids Control Council (KE)
- Ministry of Health (KE)
- Instituto Nacional de Saúde (MZ)
- Community-Campus Partnerships for Health (US)
- Instituto de Investigação Agrária de Moçambique (MZ)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1371/journal.pone.0330792
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00