Event-related potentials and behavioural correlates of cognitive functions in MS: An EEG study during symbol digit modalities test
Our EEG-SDMT paradigm identified neurophysiological correlates of SDMT performance, which was significantly affected in pwMS. Although the P5 showed longer latencies in pwMS, this component did not differentiate between cognitively impaired and preserved individuals, likely because it is still too early to capture higher-order cognitive deficits. In contrast, RTs emerged as a more reliable and sensitive indicator of cognitive performance.
Authors
- Chiara Rossi (ORCID: https://orcid.org/0000-0002-0992-8054)
- Guy Nagels (ORCID: https://orcid.org/0000-0002-2597-0383)
- Michelangelo Dini (ORCID: https://orcid.org/0000-0002-2430-8902)
- Luca Chiveri (ORCID: https://orcid.org/0000-0002-9142-0726)
- Angela Boschetti (ORCID: https://orcid.org/0009-0007-7074-6325)
- Giulia Gamberini (ORCID: https://orcid.org/0000-0001-8550-4408)
- Marta Tacchini (ORCID: https://orcid.org/0000-0001-8446-0466)
- Mariaemma Rodegher
- Letizia Turchi (ORCID: https://orcid.org/0009-0003-1990-7649)
- Letizia Leocani
- Giancarlo Comi
- Jeroen Van Schependom
Institutions
- Vrije Universiteit Brussel (BE)
- Vita-Salute San Raffaele University (IT)
- San Raffaele University of Rome (IT)
- Casa di Cura Columbus (IT)
- Universitair Ziekenhuis Brussel (BE)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1177/13524585261423416
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00