Integrated transcriptomics and single-cell analysis identify ITGAX⁺ macrophages as key immunosuppressive factors in the prostate cancer tumor microenvironment
ITGAX marks a macrophage population associated with an immunosuppressive TME and poor prognosis in PCa. These findings highlight that ITGAX⁺ macrophages may contribute to immune evasion and represent potential targets for future therapeutic investigation.
Authors
- Yi Shao (ORCID: https://orcid.org/0009-0008-2373-5006)
- Zhiqun Shang (ORCID: https://orcid.org/0000-0002-2610-6968)
- Liwei Liu (ORCID: https://orcid.org/0009-0003-3163-5586)
- Shengju Song
- Wei Wang
- Peng Zhang
- Jing Tian
Institutions
- Linyi People's Hospital (CN)
- Weihai Municipal Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Shandong Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1007/s12672-026-04737-3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00