Clinical review: Menopause hormone therapy in weight management

Following individualized risk-benefit assessment, MHT should be prescribed based on established clinical indications: moderate to severe vasomotor symptoms, prevention of osteoporosis, treatment of hypoestrogenism, or treatment of vulvovaginal symptoms. While MHT may provide indirect benefits for weight management through improvements in cardiometabolic health and improvement of menopausal symptoms that interfere with lifestyle interventions, it should not be marketed or prescribed for weight loss or obesity treatment. Comprehensive obesity treatment should focus on the four pillars: nutrition, physical activity, behavioral modification, medical interventions, including metabolic and bariatric surgery and appropriate use of FDA-approved obesity medications when indicated.