rémigén+ ® as an alginate-based hydrogel matrix with ionic components to support regenerative processes in Chronic Diabetic Wounds

AbstractChronic diabetic wounds cause substantial disability and, in severe cases, death. The wound microenvironment is dynamic, and its pH and ionic composition critically influence healing. Abnormal pH, ion levels, and ion-channel function may contribute to impaired healing. This review summarizes how pH and ions - Ca²⁺, Na⁺, K⁺ and Mg²⁺ - affect wound healing and surveys rémigén+ as an alginate-based hydrogel matrix with ionic components. The rémigén+ composition implies a synergy between the hydrating, gel-forming function of alginate and the buffering/ionic regulation provided by the phosphate group and cations. This review draws on established scientific data on alginate matrices, ionic regulation, and pH regulation in skin and wounds, as well as related studies on the effects of Ca²⁺, Mg²⁺, Na⁺, K⁺ and phosphates on skin and wound healing. The aim of the review is to connect known biochemical and physiological principles with hypotheses about how rémigén+ influences skin tissue and what evidence in the literature supports these hypotheses.Keywords: Chronic diabetic wounds; pH; ions; ionic environment; wound healing; review; rémigén+; calcium (Ca2+); sodium (Na+); potassium (K+); magnesium (Mg2+)._______________________________________________Hesh tags / Heshtags#rémigénPlus #ChronicDiabeticWounds #WoundHealing #AlginateMatrix #HydrogelTechnology #IonicEnvironment #RegenerativeProcesses #SkinMicroenvironment #MedicalBiotechnology #HealthCareSolutions #ScienceAndResearch #AdvancedWoundTreatment #ScientificReview #InnovationsInMedicine #Biomaterials #IonRegulation #PhBalance #CellularFunction #HealingProcess #HydratingEffect #TissueReconstruction #MineralSupport #ions #Ca #Mg #Na #K #SkinRegeneration #pH #sodium #potassium #calcium #magnesium-Title tagHealing Chronic Diabetic Wounds: Exploring rémigén+®'s Innovative Approach-Description tagAn in-depth review exploring how rémigén+®, an alginate-based hydrogel matrix, improves chronic diabetic wound healing by optimizing pH and ionic balance.-Keywords tagchronic diabetic wounds, rémigén+, alginate hydrogel, wound healing, pH regulation, ionic environment, calcium (Ca²⁺), sodium (Na⁺), potassium (K⁺), magnesium (Mg²⁺), skin regeneration---