Prevalence, interreader agreement, and prognostic value of high-grade and relevant strictures in individuals with primary sclerosing cholangitis

Question What is the prevalence and the interreader agreement of high-grade and relevant strictures? Are they associated with a worse prognosis in PSC? Findings High-grade and relevant strictures are relatively common in PSC and are associated with a worse prognosis; however, the agreement of their identification is unsatisfactory. Clinical relevance High-grade and relevant strictures have a role in clinical practice; however, the low interreader agreement of the interpretation of MRCP of individuals with PSC remains an unmet challenge.