Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long‐Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab‐Based Chemotherapy
Our findings demonstrate that long-term survivors of breast cancer exhibit sympathetic overdrive, vascular dysfunction, and exercise intolerance, which may contribute to increased cardiovascular disease risk in this population.
Authors
- A C Nóbrega
- Katelyn R. Ludwig (ORCID: https://orcid.org/0009-0005-0592-2711)
- Daniel H. Craighead (ORCID: https://orcid.org/0000-0002-8744-5349)
- Carlos Eduardo Negrão (ORCID: https://orcid.org/0000-0003-4652-1226)
- Flávia Neri Folchini
- Zachary S. Clayton (ORCID: https://orcid.org/0000-0003-3878-3533)
- Amanda G. Rodrigues
- Matthew J. Rossman (ORCID: https://orcid.org/0000-0001-9381-2590)
- Bruna E. Ono
- Allan R. K. Sales
- João Eduardo Izaías
- Douglas R. Seals (ORCID: https://orcid.org/0000-0002-2391-9824)
- Kátia De Angelis
- L. Testa
- Andreia M. Porcari
- Maria C. C. Irigoyen
- Priscilla S. Pentagna
- Natália A. S. Miyaguti
- Antonio Viana Nascimento‐Filho
- Artur O. Sales
- Renata Moll‐Bernardes
- Thais S. Rodrigues
- Gabrielly M. P. S. Silva
- Fernanda M. C. Colombo
- Andre L. P. Albuquerque
- Natália G. Rocha
- Gabriel F. Texeira
- Helena N. M. Rocha
- Alex A. R. Silva
Institutions
- University of Minnesota (US)
- Universidade Federal Fluminense (BR)
- University of Colorado Boulder (US)
- University of Colorado System (US)
- D’Or Institute for Research and Education (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Universidade São Francisco (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1161/jaha.125.048047
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00