Multifunctionality of TIM-3: from immunological aging to pathological progression

The connection between aging and immune dysfunction is uncovering how immunoaging processes contribute to disease. Recent data from Alzheimer’s disease, Parkinson’s disease, and adult and pediatric glioblastomas reveal a novel role for TIM3 in brain immune alteration. These findings highlight the role of TIM3 in promoting myeloid cell dysfunction toward an immunosuppressive profile. TIM3-blocking antibody treatments for central nervous system pathologies could be a new therapeutic window for healthcare systems.