Hormonal rhythm disturbance is a potential contributor to postoperative cognitive dysfunction of pituitary tumor surgery

Our study confirms that POCD is highly prevalent in patients after pituitary tumor surgery. Postoperative hormone deficiency plays a crucial role in the progression of POCD, especially ACTH and the glucocorticoids it affects. It is worth mentioning that, a novel aspect of our study is the identification of hormonal rhythms disturbance as a potential contributor to POCD, which provide valuable insights into the mechanisms of POCD in pituitary surgery. We call for more personalized and chronobiological hormone replacement therapy approaches.