From genes to diagnosis: The impact of UNC5B and DOK5 in intracranial aneurysm detection and pathogenesis
In conclusion, the UNC5B and DOK5 genes emerge as potential diagnostic biomarkers for intracranial aneurysms.There is a positive correlation between UNC5B expression and M1 macrophages and it is primarily found in fibroblasts, suggesting that increased M1 macrophages and UNC5B expression in fibroblasts may contribute to intracranial aneurysm pathogenesis.
Authors
- Aierpati Maimaiti (ORCID: https://orcid.org/0000-0002-6876-3165)
- Z. P. Wang (ORCID: https://orcid.org/0000-0002-1702-6501)
- Pengfei Wu (ORCID: https://orcid.org/0000-0002-7255-936X)
- Alimasi Abulizi
- Paziliya Akram
- Wenbo Yang
- Zekun Ma
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1371/journal.pone.0340496
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00