Targeting biofilm and virulence in <i>Pseudomonas aeruginosa</i> : AidH@SPEEK as a novel quorum-sensing inhibitor

The rising antibiotic resistance in <i>Pseudomonas aeruginosa</i> (PA) underscores the urgent need for alternative therapeutic approaches. This study highlights the potential of AidH@SPEEK as a non-antibiotic strategy to combat PA infections by targeting the quorum-sensing (QS) system, a key regulator of biofilm formation and virulence. By degrading QS signaling molecules, AidH@SPEEK disrupts bacterial communication, reduces pathogenicity, and enhances antibiotic sensitivity. The use of SPEEK as a delivery platform ensures sustained enzyme activity and biocompatibility, making it suitable for medical implants. These findings offer a promising direction for developing anti-infective materials that mitigate biofilm-associated resistance, ultimately improving clinical outcomes for high-risk patients.