Pediatric bronchiolitis disease severity is associated with immune checkpoint dysregulation
This study demonstrates that the severity of pediatric bronchiolitis is associated with the dysregulation of immune checkpoint molecules. It adds novel insight into the immunopathogenesis of bronchiolitis by focusing on early immune biomarkers beyond conventional inflammatory parameters. These findings may support risk stratification and contribute to the development of targeted therapies in future pediatric bronchiolitis management.
Authors
- Ahmet Eken (ORCID: https://orcid.org/0000-0002-5816-0686)
- Başak Nur AKYILDIZ
- Mehmet Akif Dündar (ORCID: https://orcid.org/0000-0003-3042-7999)
- Şerife Erdem (ORCID: https://orcid.org/0000-0002-2255-1685)
- Benhur Şirvan Çetin (ORCID: https://orcid.org/0000-0002-8470-4907)
- Turan Güzel (ORCID: https://orcid.org/0000-0002-0702-6313)
- Mohammad Ahmad Houran
- YILMAZ SEÇİLMİŞ
- Busra Seniz Demir
- Ekrem Unal
- Mine Asan
- Seyma Maras
- Meda Kondolot
Institutions
- Ahi Evran University (TR)
- Medical Park Gaziantep Hospital (TR)
- Kayseri Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Hasan Kalyoncu University (TR)
- University of Colorado Anschutz Medical Campus (US)
- Erciyes University (TR)
Publication Details
- Journal
- Pediatric Research
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1038/s41390-026-04853-4
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Erciyes Üniversitesi