Monocytes Defined by Platelet Interactions and Oxidative Stress Signaling Underlie HIV‐Associated Atherosclerosis
Two monocyte clusters contribute independently to vascular immune dysregulation in people living with HIV. Platelet-monocyte complex-derived macrophages promote endothelial dysfunction while adopting a profibrotic cytokine profile. CD14<sup>+</sup> monocytes show heightened oxidative signaling and stress responses, consistent with vascular activation. Together, these mechanisms may accelerate atherosclerosis development in HIV, even in the absence of traditional cardiovascular risk factors.
Authors
- Karli R. Sutton
- Giovanni Schifitto (ORCID: https://orcid.org/0000-0002-2115-4143)
- Zachary D. Boodoo
- Ruoqiao Huiyi Wang (ORCID: https://orcid.org/0000-0003-2013-4850)
- Juilee Thakar (ORCID: https://orcid.org/0000-0003-4479-4183)
- Meera V. Singh (ORCID: https://orcid.org/0000-0001-8481-1668)
- Jun‐ichi Abe
- Sanjay B. Maggirwar
- Sengathir Rajagopal
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- George Washington University (US)
- University of Rochester (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1161/jaha.125.046482
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00