Humupulusones A and B, Two Skeletally Novel Acylphloroglucinol Derivatives from <i>Humulus lupulus</i>
Two novel acylphloroglucinol derivatives, humupulusones A and B (<b>1</b> and <b>2</b>), were isolated from <i>Humulus lupulus</i>. Compound <b>1</b>, a pair of enantiomers (<b>1a</b>/<b>1b</b>), is the first acylphloroglucinol derivative with a bicyclo[2.2.2] carbon skeleton possessing a novel 5/6/6/5/5 ring system. Humupulusone B (<b>2</b>), a pair of hemiacetal tautomers, features a highly rearranged 5/6/5-fused tricyclic scaffold. Moreover, <b>1a</b> and <b>2</b> exhibited significant inhibitory effects on LPS-induced NO production in BV-2 cells with IC<sub>50</sub> values of 13.55 and 16.09 μM, respectively.
Authors
- Luping Qin (ORCID: https://orcid.org/0000-0002-5056-6497)
- HuaQiang LI
- Zhengxi Hu (ORCID: https://orcid.org/0000-0001-6119-4185)
- Lina Ji (ORCID: https://orcid.org/0000-0002-0664-833X)
- Yu Qiao (ORCID: https://orcid.org/0000-0002-2191-3875)
- Gang Li (ORCID: https://orcid.org/0000-0002-1744-5220)
- Jiacheng Weng
- Guifen Zhou
- Na Yang
- Qi Shi
- Jingjin Bai
- Siqi Li
- Chengjian Zheng
Institutions
- Zhejiang Chinese Medical University (CN)
- Hubei University of Chinese Medicine (CN)
- Zhejiang Modern Chinese Medicine and Natural Medicine Research Institute (China) (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1021/acs.orglett.6c00611
- Primary Topic
- Hops Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00