Myelomeningocele versus myeloschisis: comparison of brain development and need for CSF diversion
Patients with myeloschisis have an increased need for CSF diversion after both prenatal and postnatal repair compared to those with MMC, which may be a consequence of increased rates of hindbrain herniation. The timing of CSF diversion after prenatal repair occurs later in patients with myeloschisis, which may be a consequence of lower rates of medullary compression. These findings suggest that there may be differences in pathophysiology between lesion types and may help with patient counseling.
Authors
- Katherine H. Bligard (ORCID: https://orcid.org/0000-0002-6029-1052)
- Sasidhar Karuparti (ORCID: https://orcid.org/0000-0002-6841-3376)
- Jesse D. Vrecenak (ORCID: https://orcid.org/0000-0002-8535-7695)
- Ali Mian (ORCID: https://orcid.org/0000-0002-0675-2719)
- Francisco Narro Garcia
- Lindsay Peglar Marsala
- Ashlynn Lizer
- Sarah Smith
- Jennifer M. Strahle
- Jagruti Anadkat
Institutions
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
- University of Missouri (US)
Publication Details
- Journal
- Journal of Neurosurgery Pediatrics
- Published
- 2026-03-13
- DOI
- https://doi.org/10.3171/2025.10.peds25173
- Primary Topic
- Spinal Dysraphism and Malformations
- Type
- article
- Field-Weighted Citation Impact
- 0.00