Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients With HIV
People with HIV have higher risk for rejection after kidney transplantation but the mechanism is poorly understood. As HIV latency promotes immune dysregulation and chronic inflammation, we evaluated whether the size of the HIV latent viral reservoir (LVR) at baseline and through 52-weeks is associated with rejection in kidney transplant recipients with HIV from donors with and without HIV. Using the intact proviral DNA assay, we found no differences in the LVR between those who experienced rejection (n=14) versus those who did not (N=55) regardless of donor HIV status. These data support the feasibility of HIV+ to HIV+ organ transplantation. Clinical Trials Registration. NCT03500315.
Authors
- Charles Durand (ORCID: https://orcid.org/0000-0002-1970-0467)
- Sander S Florman (ORCID: https://orcid.org/0000-0002-1635-9136)
- Karthik Ranganna
- Asna Sulaiman
- Yolanda Eby (ORCID: https://orcid.org/0000-0002-2905-2408)
- R. Siliciano
- Emily A. Blumberg (ORCID: https://orcid.org/0000-0002-5193-6170)
- Allan B. Massie (ORCID: https://orcid.org/0000-0002-5288-5125)
- Monika Rana
- Sarah E. Benner (ORCID: https://orcid.org/0000-0002-8336-2976)
- Marcus Pereira
- Megan Morsheimer (ORCID: https://orcid.org/0000-0001-8237-3094)
- Niraj M. Desai (ORCID: https://orcid.org/0000-0002-0457-3506)
- Melissa Laird Smith (ORCID: https://orcid.org/0000-0001-7151-3207)
- A. Redd
- Sarah Hussain
- Reinaldo E. Fernández (ORCID: https://orcid.org/0000-0002-7751-6422)
- Maricar Malinis (ORCID: https://orcid.org/0000-0002-5720-9994)
- Gregory M. Laird (ORCID: https://orcid.org/0000-0003-2873-4295)
- Alexander Gilbert (ORCID: https://orcid.org/0000-0001-5069-1880)
- Xianming Zhu (ORCID: https://orcid.org/0000-0002-3317-7449)
- Ping Yang (ORCID: https://orcid.org/0000-0003-1324-3872)
- D J Brown
- Nahel Elias
- Aaron A.R. Tobian
- Rachel Friedman-Moraco
- Carlos A Q Santos
- Catherine B Small
- Shikha Mehta
- Michele I Morris
- Miruthula Tamil Selvan
- Saima Aslam
- Valentina Stosor
- Dorry L Segev
- Peter Stock
- Sapna A Mehta
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- University of Louisville (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- University of San Diego (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- MedStar Georgetown University Hospital (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- University of California San Diego (US)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
- CCC Diagnostics (United States) (US)
- Penn Center for AIDS Research (US)
- National Institute of Allergy and Infectious Diseases (US)
- Weill Cornell Medicine (US)
- New York University (US)
- Drexel University (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1093/infdis/jiag154
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00