Individualized treatment effects of CPAP on secondary cardiovascular outcomes in non-sleepy obstructive sleep apnea patients
To our knowledge, these findings provide the first evidence of individualized treatment effect estimates for CPAP therapy in obstructive sleep apnea. These results also highlight the potential for precision medicine approaches to guide treatment decisions, reduce cardiovascular disease risk, and avoid harm in susceptible individuals.
Authors
- Kavya Devarakonda (ORCID: https://orcid.org/0000-0002-4374-4670)
- Zainab Al-Taie (ORCID: https://orcid.org/0000-0003-2624-2035)
- Vaishnavi Kundel (ORCID: https://orcid.org/0000-0002-2923-9539)
- Philip M. Robson (ORCID: https://orcid.org/0000-0002-4916-970X)
- Samira Khan (ORCID: https://orcid.org/0000-0003-4480-9162)
- Mayte Suárez-Fariñas
- Vi Le
- Neomi A. Shah
- R. Doug McEvoy
- Mathias Baumert
- Craig S. Anderson
- Oren Cohen
- Kelly Loffler
Institutions
- UNSW Sydney (AU)
- The George Institute for Global Health (AU)
- Adelaide Institute for Sleep Health (AU)
- The University of Adelaide (AU)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1038/s43856-026-01457-1
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Sleep Medicine Foundation
- Stony Wold-Herbert Fund
- American Academy of Sleep Medicine Foundation
- National Heart, Lung, and Blood Institute