Hyaluronan and Syndecan‐1: Linking Glycocalyx Degradation to Development and Progression of Heart Failure With Preserved Ejection Fraction
Hyaluronan increases with age and is consistently associated with adverse cardiac remodeling across the spectrum of cardiovascular risk. In HFpEF, a manifestation of advanced cardiovascular disease, both hyaluronan and syndecan-1 associate with a higher risk of events. These findings suggest that glycocalyx degradation markers provide clinically relevant information across different stages of disease. Whether such markers may serve as therapeutic targets should be further explored.
Authors
- Nathalie Mercier (ORCID: https://orcid.org/0000-0002-3983-2336)
- Zohra Lamiral (ORCID: https://orcid.org/0000-0001-7349-7124)
- Francisco Vasques‐Nóvoa (ORCID: https://orcid.org/0000-0001-9701-8538)
- Adelino Leite‐Moreira (ORCID: https://orcid.org/0000-0001-7808-3596)
- Luca Monzo (ORCID: https://orcid.org/0000-0003-2958-943X)
- Guillaume Baudry (ORCID: https://orcid.org/0000-0002-9200-2729)
- Jérémy Lagrange (ORCID: https://orcid.org/0000-0002-0811-565X)
- Nicolas Girerd
- Céline Leroy
- Faiez Zannad
- Estela Rocha‐Oliveira
- Joao Pedro Ferreira
- Philippe Guerci
- Mohammad Jahangiri
Institutions
- Inserm (FR)
- Laboratoire des Matériaux Avancés (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- RISEBA University of Applied Sciences (LV)
- Centre d’Investigation Clinique Innovation Technologique de Nancy (FR)
- French Clinical Research Infrastructure Network (FR)
- Défaillance Cardiovasculaire Aiguë et Chronique
- Université de Lorraine (FR)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1161/jaha.125.044788
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00