Geniposide enhances cisplatin sensitivity in non-small cell lung cancer through PUMA-mediated apoptotic pathway
These findings demonstrate that geniposide enhances cisplatin sensitivity in NSCLC by activating the p53-PUMA-mediated mitochondrial apoptotic pathway, thereby providing a potential strategy for overcoming chemotherapy resistance with improved safety.
Authors
- YIXUAN WANG
- YaoZu Han
- Ting Wang (ORCID: https://orcid.org/0000-0001-6532-1110)
- Mengchao Yu
- Wenmin Hu
- Wei Han
- Chen Wang
- Jingjing Sun
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1016/j.cellsig.2026.112486
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00