Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation

This preclinical study suggests that folate may facilitate CRC progression and immune evasion by impairing CD8⁺ T cell recruitment and anti-tumor activity. These findings represent a proof-of-concept in mouse immunometabolism offering insights into potential mechanisms underlying folate-driven CRC progression and immune suppression. Broader implications for nutritional interventions or immunotherapy in patients remain speculative at this preclinical stage and would require further clinical investigation.