A Novel Anks6 Nonsense Variant Promotes Polycystic Kidney Disease in Han:SPRD-Cy Rats and its Homozygosity is Prenatally Lethal
We identified a novel nonsense variant in Anks6. The findings indicate that the absence of wild-type ANKS6 accelerates PKD development in the Han:SPRD-Cy rat, and that complete ANKS6 deficiency prevents normal embryonic development in rats.
Authors
- Agnes Fresnoza
- Vernon Wayne Dolinsky (ORCID: https://orcid.org/0000-0001-5191-4628)
- Harold M. Aukema (ORCID: https://orcid.org/0000-0002-6982-7239)
- Emily Barker
- Tanja Winter (ORCID: https://orcid.org/0000-0003-4133-7526)
- Trevor J. Pemberton (ORCID: https://orcid.org/0000-0003-1224-1146)
- Mehrafarin Ashiri
- Richard Hemming (ORCID: https://orcid.org/0000-0002-8521-1725)
- Alexandra Blant
- Bo Xiang
- Barbara Triggs-Raine
Institutions
- St. Boniface Hospital (CA)
- Shared Health (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- Kidney360
- Published
- 2026-03-11
- DOI
- https://doi.org/10.34067/kid.0000001168
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00