The efficacy and safety of Dexanest® (0.05 % injection solution) in canine neurosurgery: breed‑specific considerations

The therapeutic efficacy and safety profile of dexmedetomidine‑containing drug Dexanest® were analyzed in neurosurgical operations (hemilaminectomy, minihemilaminectomy, ventral slot) in dogs of 8 breeds with spinal pathologies. It was shown that constant rate infusion (CRI) of Dexanes®t provides more stable sedation and reduced need for additional analgesics (10 % vs 30…40 % with other administration routes). Breed-specific features were identified: brachycephalic breeds require dose adjustment; dachshunds demonstrate delayed drug elimination; while corgis, beagles, spaniels and welsh terriers tolerate standard protocols well. The proposed breed-specific recommendations improve anesthesia safety and reduce complication risks.